| Miercuri 22 Februarie 2012 |
| # | Sp | Ora | Gazde | – | Oaspeti | Predictie | Cota | Casa | Rez |
| 1 |  |
19:30 | Lierse | 0-3 | Lokeren | x/pauza | 2.05 |  |
 |
| 2 | |
19:00 | Manchester City | 4-0 | FC Porto | over 1.5 | 1.36 | |
 |
| 3 | |
19:30 | Siena | 0-1 | Catania | X/pauza | 2.10 | |
|
| 4 | |
19:00 | Asteras T | 1-0 | Kerkyra | 1 | 1.80 | |
|
| 5 |  |
17:00 | Tsonga J-W. (Fra) | 2-0 | Mahut N. (Fra) | 1 | 1.10 | |
|